DOPAMINE IN SCHIZOPHRENIA A REVIEW AND RECONCEPTUALIZATION PDF

Am J Psychiatry. Dopamine in schizophrenia: a review and reconceptualization. Comment in Am J Psychiatry. However, several new findings suggest that abnormal, although not necessarily excessive, dopamine activity is an important factor in schizophrenia.

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Am J Psychiatry. Dopamine in schizophrenia: a review and reconceptualization. Comment in Am J Psychiatry. However, several new findings suggest that abnormal, although not necessarily excessive, dopamine activity is an important factor in schizophrenia. The authors discuss these findings and their implications.

METHOD: All published studies regarding dopamine and schizophrenia and all studies on the role of dopamine in cognition were reviewed. Attention has focused on post-mortem studies, positron emission tomography, neuroleptic drug actions, plasma levels of the dopamine metabolite homovanillic acid HVA , and cerebral blood flow. RESULTS: Evidence, particularly from intracellular recording studies in animals and plasma HVA measurements, suggests that neuroleptics act by reducing dopamine activity in mesolimbic dopamine neurons.

Post-mortem studies have shown high dopamine and HVA concentrations in various subcortical brain regions and greater than normal dopamine receptor densities in the brains of schizophrenic patients.

Recent animal and human studies suggest that prefrontal dopamine neurons inhibit subcortical dopamine activity. The authors hypothesize that schizophrenia is characterized by abnormally low prefrontal dopamine activity causing deficit symptoms leading to excessive dopamine activity in mesolimbic dopamine neurons causing positive symptoms.

It would explain the concurrent presence of negative and positive symptoms. This hypothesis is testable and has important implications for treatment of schizophrenia and schizophrenia spectrum disorders.

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DOPAMINE IN SCHIZOPHRENIA A REVIEW AND RECONCEPTUALIZATION PDF

Zulutaur Evidence, particularly from intracellular recording studies in animals and plasma HVA measurements, suggests that neuroleptics act by reducing dopamine activity in mesolimbic dopamine neurons. The authors discuss these findings and their implications. This hypothesis is testable and has important implications for treatment of schizophrenia and schizophrenia spectrum disorders. SeamansNatalia Gorelova Neuropsychopharmacology However, several new findings suggest that reconnceptualization, although not necessarily excessive, dopamine activity is an important factor in schizophrenia.

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Dopamine in schizophrenia: a review and reconceptualization.

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